Contact Us

Resources

Publication: Acute hyperglycemia increases sepsis related glycocalyx degradation and endothelial cellular injury: A microfluidic study

View or download the Publication to read more
Human umbilical vein endothelial cell (HUVEC) monolayers were established in BioFlux microfluidic channels and activated with TNF. Endothelial glycocalyx (EG) integrity was indexed by shedding of the EG components as well as thickness. Endothelial cell (EC) injury/activation was indexed by soluble biomarkers. Intracellular reactive oxygen species (ROS) was by fluorescence. The investigators concluded that BioFlux may be a useful platform to study endothelial barrier function and stress conditions and allow preclinical assessment of potential therapies.

Related Resources

Microfluidic 3D intestine tumor spheroid model for efficient in vitro investigation of nanoparticular formulations

In this study the CERO 3D Incubator & Bioreactor was used for the generation of tumor spheroids from human colon cancer cell line HT29-MTX-E12. The...

Learn more

Human iPSC-derived hepatocytes in 2D and 3D suspension culture for cryopreservation and in vitro toxicity studies

The paper discusses the use of induced pluripotent stem cells (iPSCs) in various biomedical applications, specifically for toxicity testing. The authors describe their strategies for...

Learn more

Functional differentiation and scalable production of renal proximal tubular epithelial cells from human pluripotent stem

The paper presents a protocol for the large-scale production of renal proximal tubular epithelial cells (PTEC) derived from human pluripotent stem cells (hPSC). The researchers...

Learn more
See all Publications