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The taxonomic composition and distribution of bacteria within oral biofilms are determined by selective adherence processes and competitive and mutualistic interactions between species and the environment provided by the host. In this article, the investigators leveraged a BioFlux shear flow system to examine the impact of extracellular DNase enzymes on a 4-strain (Streptococcus gordonii DL1 (Challis), Staphylococcus aureus FH7 and Streptococcus mutans GS-5, Escherichia coli) microcosm biofilm. Using a BioFlux, the investigators discovered that S. gordonii SsnA plays a key role in interspecies competition within oral biofilms.